Why is antibiotic de-escalation important and how can culture results guide therapy?

• A. Reduces antimicrobial resistance; start broad-spectrum therapy when needed, then de-escalate to narrow-spectrum based on culture and sensitivity results; adjust duration accordingly.
• B. Always start with narrow-spectrum therapy and never broaden.
• C. De-escalation increases cost and reduces efficacy.
• D. It is unnecessary in most cases.

Answer: (A)