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Multiple Choice

Which of the following is a common intrinsic etiology of acute kidney injury in small animals?

Intrinsic kidney injury means direct damage to the kidney tissue itself, such as toxicity that harms the renal tubules and parenchyma. Lily ingestion (especially in cats) is a classic nephrotoxic insult that rapidly causes intrinsic AKI, and NSAID toxicity is another common intrinsic cause by damaging renal tissue and altering blood flow via reduced prostaglandin synthesis. These injuries target the kidney directly, unlike prerenal AKI from decreased perfusion (e.g., dehydration or hypovolemia) or postrenal AKI from urinary obstruction, which involve external factors affecting perfusion or drainage rather than the kidney tissue itself. So lily toxicity or NSAID toxicity fits as a common intrinsic etiology.

Intrinsic kidney injury means direct damage to the kidney tissue itself, such as toxicity that harms the renal tubules and parenchyma. Lily ingestion (especially in cats) is a classic nephrotoxic insult that rapidly causes intrinsic AKI, and NSAID toxicity is another common intrinsic cause by damaging renal tissue and altering blood flow via reduced prostaglandin synthesis. These injuries target the kidney directly, unlike prerenal AKI from decreased perfusion (e.g., dehydration or hypovolemia) or postrenal AKI from urinary obstruction, which involve external factors affecting perfusion or drainage rather than the kidney tissue itself. So lily toxicity or NSAID toxicity fits as a common intrinsic etiology.