Which feline pathogen is associated with lymphoid neoplasia and immune suppression and is typically detected with an ELISA for a matrix protein p27?

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Multiple Choice

Which feline pathogen is associated with lymphoid neoplasia and immune suppression and is typically detected with an ELISA for a matrix protein p27?

Feline leukemia virus is a retrovirus that infects hematopoietic and immune cells, leading to immune suppression and a higher risk of lymphoid neoplasia such as lymphoma. The virus expresses a matrix protein called p27, which appears in the blood and can be detected by an ELISA as a quick screen for FeLV infection. This combination—causing immune compromise and lymphoid cancers, plus p27 antigen detectability—makes FeLV the best match for the description. Feline immunodeficiency virus also causes immune suppression but is not typically diagnosed via a p27 ELISA, and feline panleukopenia or calicivirus do not characteristically present with lymphoid neoplasia or use the p27 antigen test for detection.

Feline leukemia virus is a retrovirus that infects hematopoietic and immune cells, leading to immune suppression and a higher risk of lymphoid neoplasia such as lymphoma. The virus expresses a matrix protein called p27, which appears in the blood and can be detected by an ELISA as a quick screen for FeLV infection. This combination—causing immune compromise and lymphoid cancers, plus p27 antigen detectability—makes FeLV the best match for the description. Feline immunodeficiency virus also causes immune suppression but is not typically diagnosed via a p27 ELISA, and feline panleukopenia or calicivirus do not characteristically present with lymphoid neoplasia or use the p27 antigen test for detection.

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