Which combination of findings best supports a diagnosis of immune-mediated hemolytic anemia and what is an appropriate initial management step?

• A. Microcytic non-regenerative anemia with iron deficiency; begin iron supplementation.
• B. Reticulocytosis with spherocytes on smear and a positive Coombs' test; begin corticosteroid therapy.
• C. Hemolysis with basophilic stippling and a negative Coombs' test; provide IV fluids only.
• D. Polycythemia with a normal Coombs' test; observe without treatment.

Answer: (B)