What is the mechanism of action of pimobendan?

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Multiple Choice

What is the mechanism of action of pimobendan?

Explanation:
Pimobendan works as an inodilator: it inhibits phosphodiesterase III, which raises cyclic AMP in cardiac muscle and vascular smooth muscle. The higher cAMP activates protein kinase A, increasing calcium sensitivity of the contractile apparatus in the heart (calcium sensitization) and boosting force of contraction (positive inotropy). At the same time, the rise in cAMP causes relaxation of vascular smooth muscle, producing vasodilation. So you get stronger heart contractions together with widened vessels, improving cardiac output and reducing preload/afterload. It’s not a diuretic, not a direct vasoconstrictor, and not a calcium channel blocker.

Pimobendan works as an inodilator: it inhibits phosphodiesterase III, which raises cyclic AMP in cardiac muscle and vascular smooth muscle. The higher cAMP activates protein kinase A, increasing calcium sensitivity of the contractile apparatus in the heart (calcium sensitization) and boosting force of contraction (positive inotropy). At the same time, the rise in cAMP causes relaxation of vascular smooth muscle, producing vasodilation. So you get stronger heart contractions together with widened vessels, improving cardiac output and reducing preload/afterload. It’s not a diuretic, not a direct vasoconstrictor, and not a calcium channel blocker.

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