What is commonly considered definitive confirmation for FIP?

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Multiple Choice

What is commonly considered definitive confirmation for FIP?

Explanation:
Definitive confirmation for FIP relies on histopathology. The disease causes a distinctive granulomatous vasculitis with pyogranulomatous inflammation in affected tissues, and demonstrating feline coronavirus antigen within macrophages in those lesions (usually by immunohistochemistry) confirms FIP. Other tests—CBC, radiographs, or PCR for coronavirus on tissue—can support suspicion but are not specific, since FCoV can be present in healthy cats and imaging or routine labs don’t show the characteristic tissue changes.

Definitive confirmation for FIP relies on histopathology. The disease causes a distinctive granulomatous vasculitis with pyogranulomatous inflammation in affected tissues, and demonstrating feline coronavirus antigen within macrophages in those lesions (usually by immunohistochemistry) confirms FIP. Other tests—CBC, radiographs, or PCR for coronavirus on tissue—can support suspicion but are not specific, since FCoV can be present in healthy cats and imaging or routine labs don’t show the characteristic tissue changes.

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